Loomis T A
J Assoc Off Anal Chem. 1975 Jul;58(4):645-9.
An answer to the question of whether acute and prolonged toxicity tests are good candidates for standardization is developed by reviewing (1) the factors that are presumed to influence the results of these tests and (2) the collaborative studies that have been reported in the literature. In regard to acute toxicity tests it is clear that competent laboratories give due consideration for the control of factors that are known to influence these tests. Also competent laboratories using their own procedures provide reliable results, even though the procedures vary from laboratory to laboratory. In regard to prolonged toxicity tests there are no examples of controlled collaborative investigations which could be used to evaluate interlaboratory variation and its relation to the protocols involved. It is recommended that guidelines rather than rigid protocols would be an appropriate approach for improving the quality and accuracy of these toxicologic tests. Examples of such guidelines are given.
通过审查以下内容，得出了关于急性毒性试验和长期毒性试验是否适合标准化的问题的答案：（1）据推测会影响这些试验结果的因素，以及（2）文献中报道的协作研究。关于急性毒性试验，很明显，有资质的实验室会充分考虑控制已知会影响这些试验的因素。而且，即使各实验室的程序不同，使用各自程序的有资质的实验室也能提供可靠的结果。关于长期毒性试验，没有可用于评估实验室间差异及其与所涉方案关系的对照协作研究实例。建议采用指南而非严格的方案是提高这些毒理学试验质量和准确性的适当方法。文中给出了此类指南的示例。
