使用基于苯氧基乙氧基甲基聚苯乙烯（PEM）的新型微囊化四氧化锇（PEM-MC OsO₄）进行催化不对称二羟基化反应。

Catalytic asymmetric dihydroxylation using phenoxyethoxymethyl-polystyrene (PEM)-based novel microencapsulated osmium tetroxide (PEM-MC OsO4).

作者信息

Kobayashi S, Ishida T, Akiyama R

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

出版信息

Org Lett. 2001 Aug 23;3(17):2649-52. doi: 10.1021/ol0161965.

DOI:10.1021/ol0161965

PMID:11506600

Abstract

[reaction: see text]. A phenoxyethoxymethyl-polystyrene (PEM)-based novel polymer-supported osmium catalyst has been developed. The catalyst was readily prepared from PEM polymer based on a microencapsulation technique, and asymmetric dihydroxylation of olefins has been successfully performed using (DHQD)2PHAL as a chiral ligand and K3Fe(CN)6 as a cooxidant in H2O/acetone. The catalyst was recovered quantitatively by simple filtration and reused without loss of activity several times.

摘要

[反应：见正文]。已开发出一种基于苯氧基乙氧基甲基聚苯乙烯（PEM）的新型聚合物负载锇催化剂。该催化剂基于微囊化技术由PEM聚合物轻松制备，并且在水/丙酮中使用（DHQD）2PHAL作为手性配体和K3Fe（CN）6作为共氧化剂成功进行了烯烃的不对称二羟基化反应。通过简单过滤可定量回收催化剂，并且可多次重复使用而不损失活性。