Lera M, Hayes C J
The School of Chemistry, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Org Lett. 2001 Aug 23;3(17):2765-8. doi: 10.1021/ol016366d.
[reaction: see text]. The synthesis of vinylphosphonate-linked nucleotide dimers has been achieved using an olefin cross-metathesis (CM) reaction as a key step. The 1,3-dimesityl-4,5-dihydroimidazol-2-ylidine-containing catalyst 5 (Grubbs' second-generation catalyst) was found to be the superior catalyst for this transformation. Both metathesis partners were readily available using known methodology, and the vinylphosphonate-linked dimer was produced with high levels of (E)-selectivity (>20:1) in 58% yield (70% based on recovered starting material).
[反应：见正文]。以烯烃复分解（CM）反应为关键步骤，实现了乙烯基膦酸酯连接的核苷酸二聚体的合成。发现含1,3 - 二甲基苯基 - 4,5 - 二氢咪唑 - 2 - 亚基的催化剂5（格拉布第二代催化剂）是该转化反应的优良催化剂。两种复分解反应物均可通过已知方法轻松获得，并且以58%的产率（基于回收的起始原料为70%）、高（E）-选择性（>20:1）生成了乙烯基膦酸酯连接的二聚体。
