Clinical efficacy of clenbuterol and propiverine in menopausal women with urinary incontinence: improvement in quality of life.

The present study evaluated the effects of clenbuterol and propiverine therapy on postmenopausal urinary incontinence. The patients consisted of 89 postmeopausal women with stress or urge incontinence who had consulted our out-patient clinic between March 1994 and February 1999. Patients were treated with either clenbuterol for stress incontinence or propiverine for urge incontinence. The administration period for both drugs was eight weeks. The cure rates for clenbuterol and propiverine were 41.2% and 52.6%, respectively. Both treatments significantly decreased the frequencies of incontinence, 24-h. voiding and nocturnal voiding, and both resulted in an overall clinical improvement. Furthermore, the two treatments resulted in significant subjective improvements in quality of life. We conclude that both medical treatments resulted in an improvement in urinary incontinence and contributed to overall quality of life. The present study demonstrated the necessity of contributed urinary incontinence with improvement in quality of life of postmenopausal women.