Koch J, Günther K P, Steinberger H
Dtsch Med Wochenschr. 1980 May 16;105(20):724-7. doi: 10.1055/s-2008-1070738.
Ten female patients with motor and 16 with sensory urge incontinence were treated with clenbuterol, a beta 2-sympathicomimetic drug, over a period of at least 4 weeks with a dosage of 10 microgram t.i.d. Urodynamic volumes increased significantly in sensory urge incontinence during the first and maximal urinary urgency; the tonometric index clearly decreased. Autonomous detrusor contraction, characteristic of motor urge incontinence, could be decreased or suppressed by clenbuterol. Urodynamic pressure characteristics were equally reduced significantly at first and maximal urinary urgency. In comparison, treatment of pure stress incontinence in 9 female patients led to no changes of measurements even after two weeks.
10例运动性急迫性尿失禁女性患者和16例感觉性急迫性尿失禁女性患者接受了克仑特罗治疗，克仑特罗是一种β2拟交感神经药物，治疗期至少4周，剂量为每日3次，每次10微克。在感觉性急迫性尿失禁患者中，首次出现最大尿急时，尿动力学容量显著增加；压力测定指数明显降低。克仑特罗可减少或抑制运动性急迫性尿失禁特有的自主性逼尿肌收缩。在首次出现最大尿急时，尿动力学压力特征同样显著降低。相比之下，9例单纯压力性尿失禁女性患者即使在治疗两周后测量值也无变化。
