Endo S, Inada K, Inoue Y, Yamada Y, Fujino Y, Miura M, Baba E, Sato N, Wakabayashi G, Katsuya H, Sato S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
J Med. 2000;31(5-6):320-6.
Nuclear matrix protein (NMP) is an index of apoptosis. We measured NMP in 22 patients with acute pancreatitis and investigated the relationship between severity and NMP. We also measured tumor necrosis factor-alpha (TNF-alpha) and investigated the relationship between NMP and TNF-alpha. The NMP value increased significantly as the pancreatitis became more increasingly severe, and the NMP values were significantly higher in the group with multiple organ dysfunction syndrome (MODS) than in the group without MODS. A comparison of the NMP values in the group that survived and the group that died revealed higher NMP values in the former. A significant correlation was found between the NMP values and the TNF-alpha values, suggesting that apoptosis may contribute to the pathophysiology of acute pancreatitis.
核基质蛋白（NMP）是细胞凋亡的一个指标。我们检测了22例急性胰腺炎患者的NMP，并研究了其严重程度与NMP之间的关系。我们还检测了肿瘤坏死因子-α（TNF-α），并研究了NMP与TNF-α之间的关系。随着胰腺炎病情日益加重，NMP值显著升高，多器官功能障碍综合征（MODS）组的NMP值显著高于无MODS组。存活组和死亡组的NMP值比较显示，前者的NMP值更高。NMP值与TNF-α值之间存在显著相关性，提示细胞凋亡可能参与了急性胰腺炎的病理生理过程。
