Kitamura Michihiko, Endo Shigetasu, Sato Nobuhiro, Yaegashi Yasunori, Suxzuki Yasuhi, Kojika Nasahiroi, Wakabayashi Go
Department of Surgery, Iwate Prefectural Isawa Hospital, 61 Tatsugababa, Mizusawa 023-0864, Japan.
Res Commun Mol Pathol Pharmacol. 2004;115-116:235-42.
The FasL-Fas system has been recognized as one of the apoptosis-inducing systems in the body. We studied the association between the serum levels of sFas, sFasL and TNF-alpha and the severity of the pathophysiological condition in 20 patients with multiple organ dysfunction syndrome (MODS) complicating generalized peritonitis. The serum levels of sFas and TNF-alpha were significantly higher in the patients who died than in those who survived. On the other hand, the sFasL level was significantly higher in the patients who survived than in those who died. A significant correlation was observed between the serum TNF-alpha level and the serum sFas level. These findings suggest that changes in the FasL-Fas system may be involved in the pathogenesis of MODS.
FasL-Fas系统已被公认为体内诱导细胞凋亡的系统之一。我们研究了20例并发全身性腹膜炎的多器官功能障碍综合征（MODS）患者血清sFas、sFasL和TNF-α水平与病理生理状况严重程度之间的关联。死亡患者的血清sFas和TNF-α水平显著高于存活患者。另一方面，存活患者的sFasL水平显著高于死亡患者。血清TNF-α水平与血清sFas水平之间存在显著相关性。这些发现表明，FasL-Fas系统的变化可能参与了MODS的发病机制。
