Pangan A L, Robinson D
Arthritis Unit, Massachusetts General Hospital, Boston 02114, USA.
J Rheumatol. 2001 Aug;28(8):1923-5.
Vitamin C deficiency or scurvy is a disease now rarely seen except for certain populations at risk. When it occurs, diagnosis can be difficult as it can mimic other disorders. Its manifestations are primarily due to an abnormality in collagen formation causing bleeding in the skin, joints, muscles, or gastrointestinal tract and dystrophic hair deformities. We describe a case of scurvy in a 43-year-old man who presented with new onset hemarthrosis with no history of bleeding disorder. He was found to have perifollicular hyperpigmentation and corkscrew hairs, highly suggestive of scurvy. He admitted to completely eliminating fruits and vegetables from his diet and his serum vitamin C level was markedly decreased. Treatment with daily vitamin C supplement led to relief of symptoms and resolution of skin changes.
维生素C缺乏症或坏血病是一种除某些高危人群外现在很少见的疾病。当它发生时,诊断可能很困难,因为它可能会模仿其他疾病。其表现主要是由于胶原蛋白形成异常,导致皮肤、关节、肌肉或胃肠道出血以及毛发营养不良性畸形。我们描述了一例43岁男性坏血病病例,该患者出现新发关节积血,无出血性疾病史。他被发现有毛囊周围色素沉着和螺旋状毛发,高度提示坏血病。他承认在饮食中完全排除了水果和蔬菜,其血清维生素C水平明显降低。每日补充维生素C治疗使症状得到缓解,皮肤改变也得到改善。