Espinel G H
J Clin Invest. 1975 Aug;56(2):286-91. doi: 10.1172/JCI108092.
The influence of dietary salt on the levels of plasma bicarbonate and on the characteristics of bicarbonate reabsorption was studied in experimental chronic renal failure. Chronic renal failure was produced in rats by sequential partial nephrectomies. The control group received a diet constant in salt content throughout the progression of renal failure; the other group (PRNa), at each stage of renal failure, received salt intake reduced in direct proportion to the fall in glomerular filtration rate (GFR). In the steady state, the quantities of urinary sodium closely approximated intake in obth groups of animals. The adaptive increased natriuresis per nephron exhibited by the control animals was prevented in the PRNa animals. The PRNa group had (a) higher plasma bicarbonate levels, (b) increased bicarbonate thresholds, and (c) increased maximal tubular reabsorptive capacity for bicarbonate. As renal failure progresses, dietary salt can become a determining factor of the levels at which plasma bicarbonate is maintained. Proportional reduction of dietary salt results in bicarbonate conservation in rats with experimental progressive renal failure.
在实验性慢性肾衰竭中，研究了饮食中的盐对血浆碳酸氢盐水平及碳酸氢盐重吸收特性的影响。通过连续部分肾切除术在大鼠中制造慢性肾衰竭。对照组在肾衰竭进展过程中接受盐分含量恒定的饮食；另一组（PRNa组）在肾衰竭的每个阶段，盐分摄入量与肾小球滤过率（GFR）的下降成反比减少。在稳定状态下，两组动物的尿钠量都与摄入量密切接近。对照组动物每个肾单位适应性增加的利钠作用在PRNa组动物中受到抑制。PRNa组有：（a）较高的血浆碳酸氢盐水平；（b）升高的碳酸氢盐阈值；（c）增加的肾小管对碳酸氢盐的最大重吸收能力。随着肾衰竭进展，饮食中的盐可成为维持血浆碳酸氢盐水平的决定性因素。在实验性进行性肾衰竭大鼠中，按比例减少饮食中的盐会导致碳酸氢盐潴留。
