Ptak W, Hanczakowska M
J Immunol. 1975 Sep;115(3):796-9.
Alloantibodies substantially alter the in vitro nonspecific cytotoxic effect of macrophages on bystanding allogeneic and xenogeneic target cells. Although the specific IgM alloantibody increased significantly the ability to parental macrophages to damage target cells, IgG alloantibody had an opposite effect and suppressed the macrophage cytotoxicity. Macrophages of F1 hybrid mice were less affected by this treatment unless alloantibodies against both parental strains were added together. Parental macrophages exposed in vitro to the concomitant action of both IgM and IgG alloantibodies exhibited a diminished cytotoxicity toward target cells. It is proposed that IgM and IgG alloantibodies induce different conformational changes of the macrophage surface.
同种抗体可显著改变巨噬细胞对旁立异基因和异种靶细胞的体外非特异性细胞毒性作用。尽管特异性IgM同种抗体显著增强了亲代巨噬细胞损伤靶细胞的能力，但IgG同种抗体则产生相反作用，抑制巨噬细胞的细胞毒性。除非同时加入针对两个亲本品系的同种抗体，否则F1杂种小鼠的巨噬细胞受这种处理的影响较小。体外暴露于IgM和IgG同种抗体共同作用下的亲代巨噬细胞对靶细胞的细胞毒性减弱。有人提出，IgM和IgG同种抗体可诱导巨噬细胞表面发生不同的构象变化。
