Trisolini R, Lazzari Agli L, Tassinari D, Rondelli D, Cancellieri A, Patelli M, Falcone F, Poletti V
Dept Thoracic Diseases, Bellaria and Maggiore Hospitals, Bologna, Italy.
Eur Respir J. 2001 Jul;18(1):243-5.
Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma. The findings from transbronchial lung biopsy and bronchoalveolar lavage (BAL) were consistent with an organizing diffuse alveolar damage pattern. Once extensive microbiological studies proved negative, corticosteroids were given and a complete remission of clinical and radiological abnormalities was achieved. It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.
一名60岁男性在接受奥沙利铂和5-氟尿嘧啶治疗不可切除直肠癌后，出现腹泻、T-CD4+淋巴细胞减少和双侧斑片状肺浸润。经支气管肺活检和支气管肺泡灌洗（BAL）的结果与机化性弥漫性肺泡损伤模式一致。一旦广泛的微生物学研究证明为阴性，即给予皮质类固醇治疗，临床和影像学异常完全缓解。结论是，上述病理表现是由化疗引起的，包括肺部不良反应，这是一种以前从未与奥沙利铂和5-氟尿嘧啶治疗方案相关的特征。
