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体外产生的超高分子量聚乙烯磨损颗粒的分离与形态学表征

Isolation and morphological characterisation of UHMWPE wear debris generated in vitro.

作者信息

Affatato S, Fernandes B, Tucci A, Esposito L, Toni A

机构信息

Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy.

出版信息

Biomaterials. 2001 Sep;22(17):2325-31. doi: 10.1016/s0142-9612(00)00403-8.

Abstract

Wear tests are generally carried out on materials used in prosthetic hip implants, in order to obtain a better understanding of the tribological processes involved and improve the quality control of joint prostheses, directed towards reducing the risk of implant failure of innovative prostheses. Ceramic femoral heads of mixed alumina-zirconia oxides as well as zirconia and alumina single oxide heads were tested against UHMWPE acetabular cups in a hip joint simulator. Polyethylene cups and ceramic femoral heads were mounted in a simulator apparatus moving according to a sinusoidal function, under load and in the presence of bovine calf serum as lubricant. Wear particles were isolated from the bovine calf serum collected during the wear tests. An easy to follow method was used to separate the wear particles from the lubricant. Chemical digestive methods were used to separate the wear particles from the lubricant and the isolated particles were studied using scanning electron microscopy. The morphologies of the polyethylene debris showed considerable differences, both in size and shape of the particles, as a function of the coupled head material.

摘要

通常对用于人工髋关节植入物的材料进行磨损测试,以便更好地了解其中涉及的摩擦学过程,并改进关节假体的质量控制,旨在降低创新假体植入失败的风险。在髋关节模拟器中,对混合氧化铝 - 氧化锆陶瓷股骨头以及氧化锆和氧化铝单氧化物股骨头与超高分子量聚乙烯髋臼杯进行了测试。将聚乙烯杯和陶瓷股骨头安装在根据正弦函数移动的模拟器装置中,处于负载下并在存在牛犊血清作为润滑剂的情况下。从磨损测试期间收集的牛犊血清中分离出磨损颗粒。使用一种易于遵循的方法将磨损颗粒与润滑剂分离。采用化学消化方法将磨损颗粒与润滑剂分离,并使用扫描电子显微镜对分离出的颗粒进行研究。聚乙烯碎片的形态在颗粒的大小和形状方面都表现出相当大的差异,这是耦合头部材料的函数。

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