Stone V E
Department of Medicine, Memorial Hospital of Rhode Island, Brown University School of Medicine, Providence, RI, USA.
Clin Infect Dis. 2001 Sep 15;33(6):865-72. doi: 10.1086/322698. Epub 2001 Aug 13.
Successful treatment of human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS) with highly active antiretroviral therapy (HAART) requires that patients maintain nearly perfect adherence to the prescribed regimen. Suboptimal adherence to antiretroviral therapy is clearly the most common cause of virologic failure of HAART regimens. Given the critical role of adherence in successful antiretroviral therapy, it is essential that providers of care for patients with HIV infection have a strategy that proactively assists and supports their patients' efforts to adhere to medication regimens. This review endeavors to provide a clinically focused approach to optimizing adherence of patients to HAART.
采用高效抗逆转录病毒疗法（HAART）成功治疗人类免疫缺陷病毒感染/获得性免疫缺陷综合征（HIV/AIDS），要求患者几乎完全依从规定的治疗方案。对抗逆转录病毒疗法依从性欠佳显然是HAART治疗方案病毒学失败最常见的原因。鉴于依从性在抗逆转录病毒疗法成功治疗中发挥关键作用，HIV感染患者的医疗服务提供者必须制定一项策略，积极协助并支持患者努力坚持药物治疗方案。本综述致力于提供一种以临床为重点的方法，以优化患者对HAART的依从性。
