Kijak G H, Avila M M, Salomón H
National Center for AIDS, Department of Microbiology, School of Medicine, University of Buenos Aires, Argentina.
Drug Resist Updat. 2001 Feb;4(1):29-37. doi: 10.1054/drup.2001.0182.
Mother-to-child transmission of HIV-I is responsible for the infection of hundreds of thousands of infants every year. The use of prophylactic antiretroviral treatments has brought about a dramatic decrease in the risk of transmission. Nevertheless, vertical transmission can still occur. In some cases, the presence of drug-resistant HIV-I strains in the mother has been responsible for the failure of the prophylactic scheme. Moreover, these strains have also been detected in the newborn. The aim of this review is to provide updated information on mother-to-child transmission of drug-resistant HIV strains and to help guide treatment decisions during pregnancy.
每年，母婴传播导致成千上万的婴儿感染HIV-1。预防性抗逆转录病毒治疗的使用已大幅降低了传播风险。然而，垂直传播仍可能发生。在某些情况下，母亲体内耐药HIV-1毒株的存在导致了预防方案的失败。此外，在新生儿中也检测到了这些毒株。本综述的目的是提供关于耐药HIV毒株母婴传播的最新信息，并帮助指导孕期的治疗决策。
