Bauer H I, Kaatz M, Elsner P
Klinik für Dermatologie und dermatologische Allergologie der Friedrich-Schiller-Universität Jena.
Dtsch Med Wochenschr. 2001 Jul 27;126(30):845-6. doi: 10.1055/s-2001-16016.
The case of a 70 year old male is presented. Past medical history revealed the following diagnoses: liver cirrhosis, splenomegaly, thrombocytopenia, macrocytic anaemia, chronic obstructive pulmonary disease, type IIa diabetes mellitus and peripheral vascular disease of the lower limbs with chronic leg ulcers. Within 6 weeks the patient developed an increasing number of pigmented lanugo type hair over both cheeks, zygomatic arches and temples. The diagnosis of circumscribed acquired hypertrichosis lanuginosa (AHL) was established. Bone marrow biopsy revealed presence of acute myeloid leukemia.
Chemotherapy with hydroxycarbamide (Syrea) was started without effect on haematologic parameters. The patient was transferred to the oncology unit where he died soon afterwards.
Acquired hypertrichosis lanuginosa (AHL) is a paraneoplastic syndrome. It is mainly associated with adenocarcinoma of lung and bowel, however other histologic types of tumours and localisations have been described. About 50 cases have been reported in the literature until 1998. To our knowledge this is the first case of AHL described in association with acute myeloid leukemia.
报告一名70岁男性病例。既往病史显示有以下诊断：肝硬化、脾肿大、血小板减少、大细胞性贫血、慢性阻塞性肺疾病、IIa型糖尿病以及伴有慢性腿部溃疡的下肢周围血管疾病。在6周内，患者双侧脸颊、颧弓和颞部出现越来越多的色素沉着性毳毛样毛发。确诊为局限性获得性毳毛增多症（AHL）。骨髓活检显示存在急性髓系白血病。
开始使用羟基脲（喜复宁）化疗，但对血液学参数无影响。患者被转至肿瘤科，随后不久死亡。
获得性毳毛增多症（AHL）是一种副肿瘤综合征。它主要与肺癌和肠癌腺癌相关，不过也有其他组织学类型的肿瘤及部位的相关描述。截至1998年，文献中报道了约50例。据我们所知，这是首例与急性髓系白血病相关的AHL病例。
