Veselovský J, Oláh Z, Veselá A, Gressnerová S
Katedra zivocísnej fyziológie a etológie PrF UK, Bratislava, SR.
Cesk Slov Oftalmol. 2001 Jul;57(4):219-25.
In this contribution the activity of antiglaucomatics--2% pilocarpine (pH 5.98), 0.5% timoptol (pH 6.58) and 0.005% xalatan (pH 6.83) is emphasized from the view of pH values and changes of the pH values of the rabbit aqueous humor in vitro after their application. The rabbit's aqueous humor pH is 7.59--similar to the human healthy eye (7.5-7.6). We observed that these antiglaucomatics decrease the aqueous humor pH to the acid levels in the following order: 2% pilocarpine > 0.5% timoptol > 0.005% xalatan. The most significant decrease was measured immediately after the application. From the view of speed of response and effectivity in time achieving the pH of the normal aqueous humor we constate the following order: 0.005% xalatan > 0.5% timoptol > 2% pilocarpine. The changes in pH of the aqueous humor after application of these antiglaucomatics are directly connect with their physiologic function in the eye. Moreover, they also point out the importance of the pH dependence of the antiglaucomatics applicated into the conjunctival sac in the treatment of the glaucoma disease.
在本论文中，从pH值以及兔眼房水在体外应用抗青光眼药物后的pH值变化角度，着重研究了2%毛果芸香碱（pH 5.98）、0.5%噻吗洛尔（pH 6.58）和0.005%拉坦前列素（pH 6.83）这几种抗青光眼药物的活性。兔眼房水的pH值为7.59，与人类健康眼睛的pH值（7.5 - 7.6）相似。我们观察到这些抗青光眼药物使房水pH值降低至酸性水平，其顺序为：2%毛果芸香碱＞0.5%噻吗洛尔＞0.005%拉坦前列素。应用后立即测量到的pH值下降最为显著。从响应速度和在达到正常房水pH值所需时间内的有效性来看，我们确定顺序为：0.005%拉坦前列素＞0.5%噻吗洛尔＞2%毛果芸香碱。应用这些抗青光眼药物后房水pH值的变化与其在眼中的生理功能直接相关。此外，它们还指出了结膜囊内应用抗青光眼药物时pH依赖性在青光眼疾病治疗中的重要性。
