Kaminaga T, Kobayashi M, Abe T
Department of Radiology, Teikyo University Medical School, Tokyo, Japan.
Neuroradiology. 2001 Jul;43(7):575-80. doi: 10.1007/s002340100548.
Proton magnetic resonance spectroscopy(1H-MRS) can be used for looking at cerebral metabolites in vivo. However, measurement of concentrations of cerebral metabolites in patients with disturbances of cerebral development have not been successful. Our purpose was to measure the concentrations of cerebral metabolites in such patients. We carried out quantitative 1H-MRS in eight patients with cortical dysplasia, four with lissencephaly and three with heterotopic grey matter and six age-matched normal controls. Regions of interest for 1H-MRS were set over the affected cortex in the patients and the occipital cortex in controls. The calculated concentration of N-acetylaspartate ([NAA]) was significantly lower in the affected cortex in patients with cortical dysplasia (P < 0.05), lissencephaly (P < 0.01), and heterotopia (P < 0.05) than in controls, idnicating a decreased number and/or immaturity or dysfunction of neurones in the affected cortex. The concentration of choline ([Cho]) was significantly lower in patients with lissencephaly (P < 0.01) than in controls, indicating glial proliferation and/or membrane abnormality.
质子磁共振波谱（1H-MRS）可用于在体观察脑代谢物。然而，在脑发育障碍患者中测量脑代谢物浓度尚未成功。我们的目的是测量此类患者的脑代谢物浓度。我们对8例皮质发育异常患者、4例无脑回畸形患者、3例灰质异位患者以及6名年龄匹配的正常对照进行了定量1H-MRS检查。1H-MRS的感兴趣区在患者的患侧皮质以及对照的枕叶皮质上设定。皮质发育异常患者（P < 0.05）、无脑回畸形患者（P < 0.01）和灰质异位患者（P < 0.05）患侧皮质中计算得出的N-乙酰天门冬氨酸（[NAA]）浓度显著低于对照，表明患侧皮质中神经元数量减少和/或不成熟或功能障碍。无脑回畸形患者（P < 0.01）的胆碱（[Cho]）浓度显著低于对照，表明存在胶质细胞增生和/或膜异常。
