Hashimoto T, Tayama M, Miyazaki M, Fujii E, Harada M, Miyoshi H, Tanouchi M, Kuroda Y
Department of Pediatrics, University of Tokushima, School of Medicine.
No To Hattatsu. 1994 Jan;26(1):26-31.
Volume-selective proton MR spectroscopy (1H-MRS) of the brain was performed on a 1.5 T magnet in 31 healthy children aged from 1 month to 15 years and one healthy adult. Peaks of N-acetylaspartate (NAA), choline (Cho) and creatine (Cr) were observed in all cases on 1H-MRS, but not lactate. On 1H-MRS of the right parietal region, with advancing age, 1H-MRS revealed an increase in the ratios of NAA to Cho and NAA to Cr and a decrease in Cho to Cr. The most rapid change was noted during the first one to three years of life. 1H-MRS of the right frontal region was also performed in eleven cases. The ratio of NAA/Cho was smaller in the right frontal region than in the right parietal region. From this result, it may be suggested that the neuronal maturation in the frontal region delays as compared with the parietal region.
对31名年龄在1个月至15岁的健康儿童和1名健康成人在1.5T磁体上进行了大脑的体积选择性质子磁共振波谱（1H-MRS）检查。在所有病例的1H-MRS上均观察到N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）的峰，但未观察到乳酸峰。在右侧顶叶区域的1H-MRS上，随着年龄的增长，1H-MRS显示NAA与Cho的比值以及NAA与Cr的比值增加，而Cho与Cr的比值降低。在生命的头一至三年中变化最为迅速。还对11例患者进行了右侧额叶区域的1H-MRS检查。右侧额叶区域的NAA/Cho比值低于右侧顶叶区域。从这个结果可以推测，与顶叶区域相比，额叶区域的神经元成熟延迟。
