Laurier D, Valenty M, Tirmarche M
Institute for Protection and Nuclear Safety, Risk Assessment and Management Department, IPSN/DPHD/SEGR, Fontenay-aux-Roses, France.
Health Phys. 2001 Sep;81(3):272-88. doi: 10.1097/00004032-200109000-00009.
Since the 1990's, several authors estimated that radon inhalation may deliver a small amount of irradiation to the red bone marrow, and consequently may increase the risk of leukemia in humans. The objective of this review is to conduct a critical analysis of epidemiologic results currently available concerning the relationship between radon exposure and the risk of leukemia. Nineteen ecological studies, six miner cohort studies, and eight case-control studies published between 1987 and 2000 are included in this review. The limitations associated with each of these studies are discussed. The results of the ecological studies are relatively concordant and suggest an association between radon concentrations and the risk of leukemia at a geographic level. But these ecological studies present important limitations, and some are only crude analyses. Moreover, the results of the cohort and case-control studies, based on individual data, do not show any significant association between radon exposure and leukemia risk. Our conclusion is that the overall epidemiologic results currently available do not provide evidence for an association between radon exposure and leukemia.
自20世纪90年代以来，几位作者估计，吸入氡气可能会给红骨髓带来少量辐射，因此可能会增加人类患白血病的风险。本综述的目的是对目前有关氡暴露与白血病风险之间关系的流行病学结果进行批判性分析。本综述纳入了1987年至2000年间发表的19项生态学研究、6项矿工队列研究和8项病例对照研究。讨论了这些研究各自存在的局限性。生态学研究的结果相对一致，表明在地理层面上氡浓度与白血病风险之间存在关联。但这些生态学研究存在重要局限性，有些只是粗略分析。此外，基于个体数据的队列研究和病例对照研究结果并未显示氡暴露与白血病风险之间存在任何显著关联。我们的结论是，目前可得的总体流行病学结果并未提供氡暴露与白血病之间存在关联的证据。
