Cohan S L, Fermaglich J, Auth T L
J Neurol Neurosurg Psychiatry. 1975 Feb;38(2):120-22. doi: 10.1136/jnnp.38.2.120.
A 25 year old man, with a family history of multiple sclerosis in two preceding generations, developed transient sensory changes and incoordination, initially on the left side, and then several months later on the right side in association with an elevated CSF gamma globulin. This was followed by an acute optic neuritis. During the latter episode he developed a positive brain scan which was unaccompanied by any clinical findings explained by a lesion in that area. Cerebral arteriography was normal and the brain scan returned to normal four weeks later, possibly as a result of blood brain barrier restoration. Abnormal brain scans appear to occur only during acute exacerbations of demyelinating disease, and multiple sclerosis should be part of the differential diagnosis of a positive brain scan in a person in the appropriate age range.
一名25岁男性，其前两代家族中有多发性硬化症病史，起初出现短暂的感觉变化和共济失调，最初在左侧，几个月后右侧也出现，同时脑脊液γ球蛋白升高。随后发生急性视神经炎。在后者发作期间，他脑部扫描呈阳性，但该区域病变并未伴有任何可解释的临床症状。脑血管造影正常，四周后脑扫描恢复正常，这可能是血脑屏障恢复的结果。异常的脑部扫描似乎仅在脱髓鞘疾病急性加重期出现，在合适年龄范围内的人出现脑部扫描阳性时，多发性硬化症应列入鉴别诊断。
