Haidari M, Javadi E, Sanati A, Hajilooi M, Ghanbili J
Cardiovascular Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Clin Chem. 2001 Sep;47(9):1666-72.
Body iron status has been implicated in atherosclerotic cardiovascular disease. The main hypothesis is that high iron status is associated with increased oxidation of LDL. We investigated the potential role of ferritin as an additional risk factor promoting atherosclerosis among a young population with coronary artery disease (CAD).
Four hundred consecutive patients (218 males, 182 females) referred for diagnostic coronary angiography were examined, and risk factors for CAD, lipids, C-reactive protein (CRP), and ferritin concentrations were recorded for all participants.
Ferritin was higher in the male patients with CAD (121 microg/L; range, 56-258 microg/L) than in the men without significant CAD (73 microg/L; range, 32-138 microg/L; P <0.002). Multiple logistic regression analysis, after adjustment for the established coronary risk factors, showed ferritin as an independent discriminating risk factor for CAD (P <0.01). Men in the highest quartile of ferritin had an odds ratio (OR) of 1.62 [95% confidence interval (95% CI), 1.12-2.42; P <0.01] compared with men in the lowest quartile of ferritin. The association between ferritin and CAD was more pronounced in male patients < or =50 years (OR = 2.65; 95% CI, 1.35-5.51; P <0.003). Ferritin was significantly higher in diabetic male patients in comparison with nondiabetic male patients [168 microg/L (range, 74-406 microg/L) vs 106 microg/L (range, 44-221 microg/L), respectively; P <0.002]. No association was observed between ferritin and CAD among the female patients.
Our data suggest that increased ferritin might be an independent predictor of premature CAD in male Iranian patients.
体内铁状态与动脉粥样硬化性心血管疾病有关。主要假说为高铁状态与低密度脂蛋白氧化增加有关。我们调查了铁蛋白作为促进年轻冠心病（CAD）人群动脉粥样硬化的额外危险因素的潜在作用。
对连续400例接受诊断性冠状动脉造影的患者（218例男性，182例女性）进行检查，记录所有参与者的CAD危险因素、血脂、C反应蛋白（CRP）和铁蛋白浓度。
CAD男性患者的铁蛋白水平（121μg/L；范围56 - 258μg/L）高于无明显CAD的男性（73μg/L；范围32 - 138μg/L；P<0.002）。在对已确定的冠状动脉危险因素进行调整后，多因素逻辑回归分析显示铁蛋白是CAD的独立鉴别危险因素（P<0.01）。铁蛋白处于最高四分位数的男性与处于最低四分位数的男性相比，比值比（OR）为1.62[95%置信区间（95%CI），1.12 - 2.42；P<0.01]。铁蛋白与CAD之间的关联在年龄≤50岁的男性患者中更为明显（OR = 2.65；95%CI，1.35 - 5.51；P<0.003）。糖尿病男性患者的铁蛋白水平显著高于非糖尿病男性患者[分别为168μg/L（范围74 - 406μg/L）和106μg/L（范围44 - 221μg/L）；P<0.002]。女性患者中铁蛋白与CAD之间未观察到关联。
我们的数据表明，铁蛋白升高可能是伊朗男性患者过早发生CAD的独立预测因素。
