聚合物稳定性在FtsZ的位置调控中起着重要作用。
Polymer stability plays an important role in the positional regulation of FtsZ.
作者信息
Levin P A, Schwartz R L, Grossman A D
机构信息
Department of Biology, Washington University, St. Louis, Missouri 63130, USA.
出版信息
J Bacteriol. 2001 Sep;183(18):5449-52. doi: 10.1128/JB.183.18.5449-5452.2001.
Abstract
We conducted a series of experiments examining the effect of polymer stability on FtsZ localization dynamics in Bacillus subtilis. A loss-of-function mutation in ezrA, a putative polymer-destabilizing factor, suppresses the defects in FtsZ polymer stability associated with minCD overexpression. In addition, a mutation that is predicted to stabilize the FtsZ polymer leads to the formation of polar FtsZ rings. These data support the hypothesis that carefully balanced polymer stability is important for the assembly and localization of FtsZ during the bacterial cell cycle.
摘要
我们进行了一系列实验，研究聚合物稳定性对枯草芽孢杆菌中FtsZ定位动力学的影响。ezrA是一种假定的聚合物不稳定因子，其功能丧失突变可抑制与minCD过表达相关的FtsZ聚合物稳定性缺陷。此外，一个预计能稳定FtsZ聚合物的突变会导致极性FtsZ环的形成。这些数据支持了这样一个假说，即在细菌细胞周期中，精心平衡的聚合物稳定性对于FtsZ的组装和定位很重要。
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