Bertevello P S, Seelaender M C
Departamento de Histologia e Embriologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, ão Paulo, SP, Brasil.
Braz J Med Biol Res. 2001 Sep;34(9):1161-7. doi: 10.1590/s0100-879x2001000900009.
Cancer cachexia causes disruption of lipid metabolism. Since it has been well established that the various adipose tissue depots demonstrate different responses to stimuli, we assessed the effect of cachexia on some biochemical and morphological parameters of adipocytes obtained from the mesenteric (MES), retroperitoneal (RPAT), and epididymal (EAT) adipose tissues of rats bearing Walker 256 carcinosarcoma, compared with controls. Relative weight and total fat content of tissues did not differ between tumor-bearing rats and controls, but fatty acid composition was modified by cachexia. Adipocyte dimensions were increased in MES and RPAT from tumor-bearing rats, but not in EAT, in relation to control. Ultrastructural alterations were observed in the adipocytes of tumor-bearing rat RPAT (membrane projections) and EAT (nuclear bodies).
癌症恶病质会导致脂质代谢紊乱。由于各种脂肪组织库对刺激的反应不同已得到充分证实，我们评估了恶病质对从携带Walker 256癌肉瘤大鼠的肠系膜（MES）、腹膜后（RPAT）和附睾（EAT）脂肪组织中获取的脂肪细胞的一些生化和形态学参数的影响，并与对照组进行比较。荷瘤大鼠和对照组之间组织的相对重量和总脂肪含量没有差异，但恶病质会改变脂肪酸组成。与对照组相比，荷瘤大鼠MES和RPAT中的脂肪细胞尺寸增大，但EAT中没有。在荷瘤大鼠RPAT（膜突起）和EAT（核体）的脂肪细胞中观察到超微结构改变。
