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Fenfluramine poisoning.

作者信息

Veltri J C, Temple A R

出版信息

J Pediatr. 1975 Jul;87(1):119-21. doi: 10.1016/s0022-3476(75)80086-2.

DOI:10.1016/s0022-3476(75)80086-2
PMID:1151534
Abstract

Fenfluramine is a substituted phenylethylamine structurally related to amphetamine. Within three hours following the ingestion of 1,600 mg of fenfluramine, a 17-year-old girl, who was initially agitated and had tachycardia, developed convulsions, cardiac arrhythmia, and cardiorespiratory arrest. In previously reported cases, flushing, sweating, mydriasis, tachycardia, and agitation commonly occur, as well as convulsions and abrupt cardiorespiratory arrest. The rapid onset and progression of symptoms, the short interval between ingestion and death, and the lack of responsiveness to resuscitative measures are common findings in fatal cases.

摘要

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引用本文的文献

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Cardiotoxic effects of fenfluramine hydrochloride on isolated cardiac preparations and ventricular myocytes of guinea-pigs.盐酸芬氟拉明对豚鼠离体心脏标本和心室肌细胞的心脏毒性作用。
Br J Pharmacol. 2000 Mar;129(5):843-52. doi: 10.1038/sj.bjp.0703118.
2
Letter: Poisoning with slow-release fenfluramine.信函:缓释芬氟拉明中毒。
Br Med J. 1975 Nov 22;4(5994):462-3. doi: 10.1136/bmj.4.5994.462-c.