大量服用苯海拉明导致死亡。

Massive diphenhydramine overdose resulting in death.

作者信息

Krenzelok E P, Anderson G M, Mirick M

出版信息

Ann Emerg Med. 1982 Apr;11(4):212-3. doi: 10.1016/s0196-0644(82)80501-5.

Abstract

Overdosage of diphenhydramine may result in the development of anticholinergic symptoms, seizures, and coma. A fatal outcome following a diphenhydramine overdose does not commonly occur. This report describes the largest documented overdosage of diphenhydramine (7.5 g) which resulted in the death of a 14-year-old girl. The patient initially developed seizures following by cardiac conduction and hemodynamic compromise resulting in death despite life support measures.

摘要

苯海拉明过量可能导致抗胆碱能症状、癫痫发作和昏迷。苯海拉明过量后通常不会出现致命后果。本报告描述了有记录以来最大剂量的苯海拉明过量事件（7.5克），该事件导致一名14岁女孩死亡。患者最初出现癫痫发作，随后出现心脏传导和血流动力学障碍，尽管采取了生命支持措施仍导致死亡。