Brown D T
Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Genome Biol. 2001;2(7):REVIEWS0006. doi: 10.1186/gb-2001-2-7-reviews0006. Epub 2001 Jul 5.
In most eukaryotes, histones, which are the major structural components of chromatin, are expressed as a family of sequence variants encoded by multiple genes. Because different histone variants can contribute to a distinct or unique nucleosomal architecture, this heterogeneity can be exploited to regulate a wide range of nuclear functions, and evidence is accumulating that histone variants do indeed have distinct functions.
在大多数真核生物中，组蛋白作为染色质的主要结构成分，由多个基因编码的一系列序列变体来表达。由于不同的组蛋白变体可形成独特的核小体结构，这种异质性可用于调控多种核功能，并且越来越多的证据表明组蛋白变体确实具有独特的功能。
