Sanders M J, Dietrich W D, Green E J
Department of Psychology, University of Miami School of Medicine, Miami, FL, USA.
Brain Res. 2001 Jun 15;904(1):141-4. doi: 10.1016/s0006-8993(01)02424-6.
Metabolic dysfunction in the relay nuclei of the rat vibrissa circuit follows traumatic brain injury (TBI). This study examined the effects of mild (1.4-1.5 atm) parasagittal fluid-percussion injury on the electrophysiology of this circuit. TBI caused significant reductions in slope and increases in latency of vibrissa-evoked field potentials 3 days after injury. Assessment of open-field swimming revealed an increase in thigmotaxis 2 days after injury. TBI caused mild selective cortical damage and limited axonal swelling at the injury site. Thus mild injury disrupts somatosensory electrophysiology and exploratory behavior.
大鼠触须回路中继核中的代谢功能障碍发生在创伤性脑损伤（TBI）之后。本研究检测了轻度（1.4 - 1.5个大气压）矢状旁流体冲击伤对该回路电生理学的影响。创伤性脑损伤导致损伤后3天触须诱发场电位的斜率显著降低和潜伏期增加。旷场游泳评估显示损伤后2天趋触性增加。创伤性脑损伤导致轻度的选择性皮质损伤和损伤部位有限的轴突肿胀。因此，轻度损伤会破坏体感电生理学和探索行为。
