Bomzon A, Ljubuncic P
Department of Pharmacology, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Haifa, Israel.
Pharmacol Ther. 2001 Mar;89(3):295-308. doi: 10.1016/s0163-7258(01)00129-2.
Reactive oxygen species and reactive nitroxy species are now being recognized as regulatory molecules in signaling pathways influencing contractile and noncontractile functions of healthy vascular smooth muscle cells. In liver disease, oxidative stress is a systemic phenomenon, whose extent correlates with the severity of disease. A role for oxidative stress in the development of the hyperdynamic circulation in portal hypertension has been proposed. Evaluation of the limited available data indicates that it is premature to conclude that oxidative stress per se impacts on vascular smooth muscle cell function in liver disease.
活性氧和活性氮氧化物如今被认为是信号通路中的调节分子，这些信号通路会影响健康血管平滑肌细胞的收缩和非收缩功能。在肝脏疾病中，氧化应激是一种全身性现象，其程度与疾病的严重程度相关。有人提出氧化应激在门静脉高压高动力循环的发展中起作用。对现有有限数据的评估表明，现在就得出氧化应激本身会影响肝脏疾病中血管平滑肌细胞功能的结论还为时过早。
