非洲爪蟾变态的多种发育程序受到显性负性甲状腺激素受体的抑制。
Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor.
作者信息
Schreiber A M, Das B, Huang H, Marsh-Armstrong N, Brown D D
机构信息
Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10739-44. doi: 10.1073/pnas.191361698. Epub 2001 Aug 21.
Abstract
Metamorphosis of anuran tadpoles is controlled by thyroid hormone (TH). Here we demonstrate that transgenic Xenopus laevis tadpoles expressing a dominant negative form of TH receptor-alpha are resistant to a wide variety of the metamorphic changes induced by TH. This result confirms that TH receptors mediate both early and late developmental programs of metamorphosis as diverse as growth in the brain, limb buds, nose and Meckel's cartilage, remodeling of the intestine, and death and resorption of the gills and tail.
摘要
蛙类蝌蚪的变态发育由甲状腺激素（TH）控制。在此我们证明，表达TH受体α显性负性形式的转基因非洲爪蟾蝌蚪对TH诱导的多种变态变化具有抗性。这一结果证实，TH受体介导了变态发育的早期和晚期发育程序，这些程序包括大脑、肢芽、鼻子和梅克尔软骨的生长、肠道重塑以及鳃和尾巴的死亡与吸收等多种变化。
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本文引用的文献
1
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Neuron. 1999 Dec;24(4):871-8. doi: 10.1016/s0896-6273(00)81034-x.
2
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.缺乏所有已知甲状腺激素受体的小鼠能够存活，但表现出垂体 - 甲状腺轴、生长和骨骼成熟方面的紊乱。
Genes Dev. 1999 May 15;13(10):1329-41. doi: 10.1101/gad.13.10.1329.
3
Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase.在过度表达III型脱碘酶的转基因非洲爪蟾蝌蚪中，变态受到抑制。
Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):962-7. doi: 10.1073/pnas.96.3.962.
4
Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development.甲状腺激素受体TRα和TRβ在甲状腺激素产生调控及出生后发育中的不同功能。
EMBO J. 1999 Feb 1;18(3):623-31. doi: 10.1093/emboj/18.3.623.
5
The expression pattern of thyroid hormone response genes in the tadpole tail identifies multiple resorption programs.蝌蚪尾巴中甲状腺激素反应基因的表达模式确定了多种吸收程序。
Dev Biol. 1998 Nov 1;203(1):12-23. doi: 10.1006/dbio.1998.8974.
6
Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis.甲状腺激素和9-顺式视黄酸受体都是有效介导甲状腺激素对非洲爪蟾胚胎发育和特定基因调控作用所必需的。
Mol Cell Biol. 1997 Aug;17(8):4738-49. doi: 10.1128/MCB.17.8.4738.
7
8
Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail.甲状腺激素诱导源自蝌蚪尾巴的成肌细胞系发生凋亡及CPP32表达。
J Biol Chem. 1997 Feb 21;272(8):5122-7. doi: 10.1074/jbc.272.8.5122.
9
Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation.精子核移植获得的转基因非洲爪蟾胚胎揭示了原肠胚形成过程中FGF信号的需求。
Development. 1996 Oct;122(10):3173-83. doi: 10.1242/dev.122.10.3173.
10
Regionally regulated conversion of protein expression in the skin during anuran metamorphosis.
J Exp Zool. 1996 Feb 15;274(3):187-92. doi: 10.1002/(sici)1097-010x(19960215)274:3<181::aid-jez5>3.0.co;2-k.
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