Prorokov V V, Zalit N Iu, Knysh V I, Barkanov A I, Anan'ev V S
Khirurgiia (Mosk). 2001(6):38-42.
Efficacy of combined treatment (203 patients) and surgical treatment (200 patients) alone was analyzed. In combined treatment either radiation therapy (RT) in the dose 20 Gy over 5 days (group 1) or hypoxyradiotherapy (HRT) in the same doses but in combination with hypoxia (10% oxygen and 90% nitrogen--hypoxic gas mixture HGM-10--group 2) were used in preoperative period. In group 3 HGM-9 (9% oxygen and 91% nitrogen) was used as radioprotector in preoperative period but in increased by 25% radiation doses: total 25 Gy, 5 Gy for 5 days. In the control group only radical surgical treatment was performed. Preoperative irradiation didn't increase the rate of postoperative complications. At the same time the 5-year survival rate was higher in all the groups of patients on combined treatment than in the group of patients on surgical radical treatment. In the group with HGM-9 and increased by 25% radiation doses postoperative complications rate was lower, recurrences and distant metastases occurred less frequently.
分析了联合治疗（203例患者）和单纯手术治疗（200例患者）的疗效。在联合治疗中，术前阶段采用两种方式：一种是5天内给予20 Gy的放射治疗（第1组），另一种是给予相同剂量但联合低氧环境（10%氧气和90%氮气——低氧气体混合物HGM - 10——第2组）的低氧放射治疗。在第3组中，术前阶段使用HGM - 9（9%氧气和91%氮气）作为辐射防护剂，但放射剂量增加25%：总共25 Gy，5天内每天5 Gy。对照组仅进行根治性手术治疗。术前放疗并未增加术后并发症的发生率。同时，联合治疗的所有患者组的5年生存率均高于根治性手术治疗组的患者。在使用HGM - 9且放射剂量增加25%的组中，术后并发症发生率较低，复发和远处转移的发生频率也较低。
