小鼠唾液腺和蛇毒中的神经生长因子对新生及发育中小鼠交感神经节的影响。
Effects of nerve growth factors from mouse salivary glands and snake venom on the sympathetic ganglia of neonatal and developing mice.
作者信息
Banks B E, Charlwood K A, Edwards D C, Vernon C A, Walter S J
出版信息
J Physiol. 1975 May;247(2):289-98. doi: 10.1113/jphysiol.1975.sp010932.
Abstract
- Quantitative histological analysis has been made of the effects of nerve growth factor (NGF) from mouse submaxillary gland and from the venom of Vipera russelli on superior cervical ganglia of neonatal mice. 2. The hypertrophic and hyperplastic effects reported by other workers have been confirmed. 3. The hypertrophic effect arises from an increase in the rate at which the sympathetic neurones attain their mature size. The size at maturity is never exceeded. 4. The hyperplastic effect arises from an increase in the rate of production of neurones from less differentiated cells. In the developmental period, the number of neurones can exceed that found at maturity. If injection of NGF is discontinued the excess neurones disappear. 5. If injection of NGF is continued to maturity, the excess number of neurones is maintained.
摘要
- 已对来自小鼠颌下腺的神经生长因子（NGF）以及来自蝰蛇毒液的神经生长因子对新生小鼠颈上神经节的作用进行了定量组织学分析。2. 其他研究人员报道的肥大和增生效应得到了证实。3. 肥大效应源于交感神经元达到其成熟大小的速率增加。成熟时的大小从未超过该值。4. 增生效应源于从分化程度较低的细胞产生神经元的速率增加。在发育阶段，神经元的数量可以超过成熟时发现的数量。如果停止注射NGF，多余的神经元就会消失。5. 如果持续注射NGF直至成熟，多余的神经元数量将得以维持。
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