Kanno N, LeSage G, Glaser S, Alpini G
Department of Internal Medicine, Scott & White Hospital and Texas A&M University System Health Science Center, College of Medicine, TX 76504, USA.
Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G612-25. doi: 10.1152/ajpgi.2001.281.3.G612.
The objective of this review article is to discuss the role of secretin and its receptor in the regulation of the secretory activity of intrahepatic bile duct epithelial cells (i.e., cholangiocytes). After a brief overview of cholangiocyte functions, we provide an historical background for the role of secretin and its receptor in the regulation of ductal secretion. We review the newly developed experimental in vivo and in vitro tools, which lead to understanding of the mechanisms of secretin regulation of cholangiocyte functions. After a description of the intracellular mechanisms by which secretin stimulates ductal secretion, we discuss the heterogeneous responses of different-sized intrahepatic bile ducts to gastrointestinal hormones. Furthermore, we outline the role of a number of cooperative factors (e.g., nerves, alkaline phosphatase, gastrointestinal hormones, neuropeptides, and bile acids) in the regulation of secretin-stimulated ductal secretion. Finally, we discuss other factors that may also play an important role in the regulation of secretin-stimulated ductal secretion.
这篇综述文章的目的是讨论促胰液素及其受体在调节肝内胆管上皮细胞（即胆管细胞）分泌活性中的作用。在简要概述胆管细胞功能后，我们提供了促胰液素及其受体在调节导管分泌中作用的历史背景。我们回顾了新开发的体内和体外实验工具，这些工具有助于理解促胰液素调节胆管细胞功能的机制。在描述促胰液素刺激导管分泌的细胞内机制后，我们讨论了不同大小的肝内胆管对胃肠激素的异质性反应。此外，我们概述了一些协同因子（如神经、碱性磷酸酶、胃肠激素、神经肽和胆汁酸）在调节促胰液素刺激的导管分泌中的作用。最后，我们讨论了其他可能在调节促胰液素刺激的导管分泌中起重要作用的因素。
