高能量、蔗糖和多不饱和脂肪酸的摄入与先兆子痫风险增加有关。

High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsia.

作者信息

Clausen T, Slott M, Solvoll K, Drevon C A, Vollset S E, Henriksen T

机构信息

Department of Obstetrics and Gynecology, Aker University Hospital, Oslo, Norway.

出版信息

Am J Obstet Gynecol. 2001 Aug;185(2):451-8. doi: 10.1067/mob.2001.116687.

DOI:10.1067/mob.2001.116687

PMID:11518908

Abstract

OBJECTIVE

Preeclampsia is associated with high body mass index, insulin resistance, and hypertriglyceridemia. Our objective was to investigate prospectively whether diet in the first half of pregnancy is associated with the risk for preeclampsia.

STUDY DESIGN

This prospective, population-based, cohort study of pregnant women investigated dietary intake early in the second trimester with a quantitative food frequency questionnaire.

RESULTS

The questionnaire was completed by 3133 women (83%). Preeclampsia developed in 85 women. Adjusted odds ratio (95% CI) for preeclampsia was 3.7 (1.5-8.9) for energy intake of >3350 kcal/d compared with < or =2000 kcal/d. Adjusted odds ratio (95% CI) for preeclampsia was 3.6 (1.3-9.8) for sucrose intake (percent of total energy) of >25% compared with < or =8.5% and 2.6 (1.3-5.4) for polyunsaturated fatty acids intake (percent of total energy) of >7.5% compared with < or =5.2%. Other energy-providing nutrients were not associated with the risk for preeclampsia.

CONCLUSION

The current study suggests that high intakes of energy, sucrose, and polyunsaturated fatty acids independently increase the risk for preeclampsia.

摘要

目的

子痫前期与高体重指数、胰岛素抵抗及高甘油三酯血症相关。我们的目的是前瞻性研究孕期前半期的饮食是否与子痫前期风险相关。

研究设计

这项针对孕妇的前瞻性、基于人群的队列研究，在孕中期早期使用定量食物频率问卷调查饮食摄入量。

结果

3133名女性（83%）完成了问卷。85名女性发生了子痫前期。能量摄入量>3350千卡/天与≤2000千卡/天相比，子痫前期的校正比值比（95%可信区间）为3.7（1.5 - 8.9）。蔗糖摄入量（占总能量的百分比）>25%与≤8.5%相比，子痫前期的校正比值比（95%可信区间）为3.6（1.3 - 9.8）；多不饱和脂肪酸摄入量（占总能量的百分比）>7.5%与≤5.2%相比，子痫前期的校正比值比为2.6（1.3 - 5.4）。其他提供能量的营养素与子痫前期风险无关。