Ostlund Ingrid, Haglund Bengt, Hanson Ulf
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Eur J Obstet Gynecol Reprod Biol. 2004 Mar 15;113(1):12-6. doi: 10.1016/j.ejogrb.2003.07.001.
To determine whether gestational diabetes mellitus (GDM) increases the risk for preeclampsia independent of other risk factors.
The association between GDM and preeclampsia was analyzed in a population of women who had given birth to singletons registered in Swedish Medical Birth Register from 1992 through 1996 (n=430,852).
GDM occurred in 0.8% and preeclampsia in 2.9% of all pregnancies. The rate of preeclampsia was higher in the GDM than in the non-GDM group (6.1% versus 2.8%). High age, nullipara, chronic hypertension, kidney disease, and high body mass index (BMI) were all independently associated with increased risk for preeclampsia. Smoking was associated with decreased risk. Adjusted odds ratio for GDM as a risk factor for preeclampsia was 1.61 (95% confidence interval (CI) 1.39-1.86) when prepregnancy BMI, which was a true confounder, was included in the last step of the multiple logistic regression analysis.
There is an independent and significant association between GDM and preeclampsia. Obesity is a major confounding factor but could not explain the total excess risk.
确定妊娠糖尿病（GDM）是否独立于其他危险因素增加子痫前期的风险。
在1992年至1996年在瑞典医学出生登记处登记的单胎分娩女性人群（n = 430,852）中分析GDM与子痫前期之间的关联。
所有妊娠中GDM发生率为0.8%，子痫前期发生率为2.9%。GDM组子痫前期发生率高于非GDM组（6.1%对2.8%）。高龄、初产妇、慢性高血压、肾脏疾病和高体重指数（BMI）均与子痫前期风险增加独立相关。吸烟与风险降低相关。当将孕前BMI（一个真正的混杂因素）纳入多因素逻辑回归分析的最后一步时，GDM作为子痫前期危险因素的调整优势比为1.61（95%置信区间（CI）1.39 - 1.86）。
GDM与子痫前期之间存在独立且显著的关联。肥胖是一个主要的混杂因素，但不能解释全部额外风险。
