Motohashi N
National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP).
Nihon Rinsho. 2001 Aug;59(8):1519-22.
Selective serotonin reuptake inhibitors(SSRIs) are safe antidepressants and now widely used for the treatment of depression. Although there are five SSRIs(citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) available in the world, only two(fluvoxamine and paroxetine) are approved in Japan. SSRIs are also used for the treatment of obsessive-compulsive disorders, panic disorders, eating disorders and so on. Major side effects of SSRIs are gastrointestinal symptoms(especially nausea), neurological symptoms (particularly headache and tremor) and psychiatric symptoms(especially anxiety). While therapeutic effects of SSRIs seem to be related to desensitization of somatodendritic serotonin 1A autoreceptors in the raphe nuclei, other neurotransmitters and intracellular mechanisms may be also involved.
选择性5-羟色胺再摄取抑制剂（SSRIs）是安全的抗抑郁药，目前广泛用于治疗抑郁症。虽然全球有五种SSRIs（西酞普兰、氟西汀、氟伏沙明、帕罗西汀、舍曲林），但在日本仅批准了两种（氟伏沙明和帕罗西汀）。SSRIs还用于治疗强迫症、恐慌症、饮食失调等。SSRIs的主要副作用是胃肠道症状（尤其是恶心）、神经症状（特别是头痛和震颤）和精神症状（尤其是焦虑）。虽然SSRIs的治疗效果似乎与中缝核中躯体树突状5-羟色胺1A自身受体的脱敏有关，但其他神经递质和细胞内机制可能也参与其中。
