Okazaki Y
Department of Psychiatry, Mie University School of Medicine.
Nihon Rinsho. 2001 Aug;59(8):1555-9.
Mood disorders--maternity blues, depression and bipolar disorders with psychotic features--are common and increased in rate during the postpartum period as compared to the non-postpartum period. Several authors showed a frequent recurrence of postpartum depression in women with a history of postpartum depression. Bloch, et al: (2000) showed that 5 of 8 women(62.5%) with a history of postpartum depression and none of the 8 control women developed significant mood symptoms during the withdrawal from high serum levels of progesterone and estradiol. These findings indicate that a history of postpartum depression produces hypersensitivity or reverse tolerance to subsequent exposure to an acute decrease of gonadal steroids at least for a subgroup of women with a past postpartum depression.
情绪障碍——产后抑郁、伴有精神病性特征的抑郁症和双相情感障碍——很常见，与非产后时期相比，产后时期的发病率有所上升。几位作者指出，有产后抑郁病史的女性产后抑郁复发频繁。布洛赫等人（2000年）表明，8名有产后抑郁病史的女性中有5名（62.5%），而8名对照女性中没有一人在血清孕酮和雌二醇水平从高水平下降的过程中出现明显的情绪症状。这些发现表明，至少对于一部分有产后抑郁病史的女性亚组来说，产后抑郁病史会导致对随后性腺类固醇急性减少的超敏反应或反向耐受性。
