Waddell B L, Zahm S H, Baris D, Weisenburger D D, Holmes F, Burmeister L F, Cantor K P, Blair A
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Cancer Causes Control. 2001 Aug;12(6):509-17. doi: 10.1023/a:1011293208949.
Data from three population-based case-control studies conducted in Kansas, Nebraska, Iowa, and Minnesota were pooled to evaluate the relationship between the use of organophosphate pesticides and non-Hodgkin's lymphoma (NHL) among white male farmers.
The data set included 748 cases of non-Hodgkin's lymphoma and 2236 population-based controls. Telephone or in-person interviews were utilized to obtain information on the use of pesticides. Odds ratios (OR) adjusted for age, state of residence, and respondent status, as well as other pesticide use where appropriate, were estimated by logistic regression.
Use of organophosphate pesticides was associated with a statistically significant 50% increased risk of NHL, but direct interviews showed a significantly lower risk (OR = 1.2) than proxy interviews (OR = 3.0). Among direct interviews the risk of small lymphocytic lymphoma increased with diazinon use (OR = 2.8), after adjustment for other pesticide exposures.
Although we found associations between the risk of NHL and several groupings and specific organophosphate pesticides, larger risks from proxy respondents complicate interpretation. Associations, however, between reported use of diazinon and NHL, particularly diffuse and small lymphocytic lymphoma, among subjects providing direct interviews are not easily discounted.
汇总在堪萨斯州、内布拉斯加州、爱荷华州和明尼苏达州开展的三项基于人群的病例对照研究的数据，以评估白人男性农民使用有机磷农药与非霍奇金淋巴瘤（NHL）之间的关系。
数据集包括748例非霍奇金淋巴瘤病例和2236名基于人群的对照。通过电话或面对面访谈获取农药使用信息。通过逻辑回归估计经年龄、居住州和受访者状态调整后的优势比（OR），以及在适当情况下的其他农药使用情况。
使用有机磷农药与NHL风险在统计学上显著增加50%相关，但直接访谈显示的风险（OR = 1.2）明显低于代理访谈（OR = 3.0）。在直接访谈中，在调整其他农药暴露因素后，使用二嗪农会使小淋巴细胞淋巴瘤风险增加（OR = 2.8）。
尽管我们发现NHL风险与几种分类及特定有机磷农药之间存在关联，但代理受访者报告的更高风险使解读变得复杂。然而，在提供直接访谈的受试者中，报告使用二嗪农与NHL之间的关联，尤其是弥漫性和小淋巴细胞淋巴瘤，不容轻易忽视。
