用于毛细管电色谱的易于制备的连续床层上羟基酸的对映体拆分
Enantioseparation of hydroxy acids on easy-to-prepare continuous beds for capillary electrochromatography.
作者信息
Schmid M G, Grobuschek N, Lecnik O, Gübitz G, Végvári A, Hjertén S
机构信息
Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Graz, Austria.
出版信息
Electrophoresis. 2001 Aug;22(12):2616-9. doi: 10.1002/1522-2683(200107)22:12<2616::AID-ELPS2616>3.0.CO;2-G.
Abstract
This paper deals with the enantioseparation of hydroxy acids by ligand-exchange capillary electrochromatography. A chiral continuous bed was easily prepared by in situ polymerization of monomers, including an L-4-hydroxyproline derivative. This phase showed chiral recognition for several hydroxy acids, in addition to amino acids.
摘要
本文研究了通过配体交换毛细管电色谱法对羟基酸进行对映体拆分。通过包括L-4-羟基脯氨酸衍生物在内的单体原位聚合，轻松制备了手性连续床。除氨基酸外，该固定相对几种羟基酸也表现出手性识别能力。
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