Ohshiro Y, Ueda K, Wakasaki H, Takasu N, Nanjo K
First Department of Medicine, Wakayama University of Medical Science, 811-1 Kimi-idera, Wakayama 641-8509, Japan.
Biochem Biophys Res Commun. 2001 Aug 31;286(4):678-80. doi: 10.1006/bbrc.2001.5450.
The GNB3 825C/T polymorphism, which is common worldwide, is associated with enhanced G-protein activation. The frequency of 825-T allele was increased with body mass index (BMI) and finally had a high frequency in relatively mild obese (BMI >27 kg/m(2)) subjects in some populations. In the present study, we investigated 208 severely obese [BMI >or=30 kg/m(2) (97th percentile)] Japanese subjects including 146 probands with diabetes. No increase in the 825-T allele frequency was observed in the 208 severely obese and even in a subgroup of the 55 most obese [BMI >or=35 kg/m(2) (99.7th percentile)] subjects compared with that in 150 controls (BMI <25 kg/m(2)) (0.48 and 0.48 vs 0.51, respectively). Also, the frequency was not increased in the 146 obese subjects with diabetes (0.48). We concluded that the 825-T allele is not associated with obesity or diabetes associated with obesity at least in the Japanese population.
全球普遍存在的GNB3 825C/T多态性与G蛋白激活增强有关。825-T等位基因的频率随体重指数（BMI）增加，在某些人群中，相对轻度肥胖（BMI>27 kg/m²）的受试者中该等位基因频率最终较高。在本研究中，我们调查了208名重度肥胖[BMI≥30 kg/m²（第97百分位数）]的日本受试者，其中包括146名患有糖尿病的先证者。与150名对照者（BMI<25 kg/m²）相比，在这208名重度肥胖受试者中，甚至在55名最肥胖[BMI≥35 kg/m²（第99.7百分位数）]受试者的亚组中，均未观察到825-T等位基因频率增加（分别为0.48、0.48和0.51）。此外，146名患有糖尿病的肥胖受试者中该等位基因频率也未增加（0.48）。我们得出结论，至少在日本人群中，825-T等位基因与肥胖或肥胖相关的糖尿病无关。
