Ha Eunyoung, Yang Seon-Hee, Yoo Kyung-Im, Chung In-Sung, Lee Mi-Young, Bae Jae-Hoon, Seo Jung-Chul, Chung Joo-Ho, Shin Dong-Hoon
Department of Biochemistry, School of Medicine and Institute for Medical Science, Keimyung University, Daegu, Republic of Korea.
Life Sci. 2008 May 7;82(19-20):1040-3. doi: 10.1016/j.lfs.2008.03.012. Epub 2008 Apr 3.
A body of evidence indicates obesity is an inflammatory state with chronic activation of the immune system. The interleukin 4 receptor (IL4R) single nucleotide polymorphism (SNP), rs 180275 (1902A>G) is well recognized for its association with atopy and other inflammatory diseases. We assessed the possible association of rs 180275 and rs 1805010 with obesity in Korean population. Study subject consisting of 876 Koreans were divided into three groups: subjects with 1) BMI<25, 2) BMI between 25 and 27, and 3) BMI>27. Analyses of genotype distributions and allele frequencies of study subjects revealed that rs 180275 polymorphism was associated with an increase in BMI in Korean population (P=0.009 and 0.011, respectively) while no association was found between rs 1805010 and obesity. We observed significantly lower percentage of rs 180275 G allele in subjects with BMI>27 than in subjects with BMI< or =27 (9.9% vs. 16.0%). Logistic regression analysis revealed that the odds ratio (OR) for an increase in BMI associated with the G vs. A allele was 0.57 [95% Confidence interval (CI)=0.39-0.85, p=0.002], which strongly implicates the protective role of rs 180275 G allele against an increase in BMI. Haplotype analysis revealed no association was present between rs 180275 and rs 1805010 polymorphisms. The frequency of rs 180275 G allele is significantly lower in subjects with BMI>27, suggesting the protective role of IL4R rs 180275 G allele against an increase in BMI in Korean population.
大量证据表明，肥胖是一种免疫系统长期激活的炎症状态。白细胞介素4受体（IL4R）单核苷酸多态性（SNP），即rs 180275（1902A>G），因其与特应性疾病及其他炎症性疾病的关联而广为人知。我们评估了rs 180275和rs 1805010与韩国人群肥胖之间的可能关联。研究对象为876名韩国人，分为三组：1）BMI<25的受试者；2）BMI在25至27之间的受试者；3）BMI>27的受试者。对研究对象的基因型分布和等位基因频率分析显示，rs 180275多态性与韩国人群BMI增加有关（P值分别为0.009和0.011），而rs 1805010与肥胖之间未发现关联。我们观察到，BMI>27的受试者中rs 180275 G等位基因的百分比显著低于BMI≤27的受试者（9.9%对16.0%）。逻辑回归分析显示，与G等位基因相比，A等位基因导致BMI增加的优势比（OR）为0.57 [95%置信区间（CI）=0.39 - 0.85，p = 0.002]，这有力地表明rs 180275 G等位基因对BMI增加具有保护作用。单倍型分析显示，rs 180275和rs 1805010多态性之间不存在关联。BMI>27的受试者中rs 180275 G等位基因的频率显著较低，表明IL4R rs 180275 G等位基因对韩国人群BMI增加具有保护作用。
