来自东方乌檀树皮的新吲哚生物碱。

New indole alkaloids from the bark of Nauclea orientalis.

作者信息

Zhang Z, ElSohly H N, Jacob M R, Pasco D S, Walker L A, Clark A M

机构信息

National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, Mississippi 38677, USA.

出版信息

J Nat Prod. 2001 Aug;64(8):1001-5. doi: 10.1021/np010042g.

DOI:10.1021/np010042g

PMID:11520214

Abstract

Four new alkaloids, nauclealines A (1) and B (2) and naucleosides A (3) and B (4), together with six known compounds, strictosamide (5), vincosamide (6), pumiloside (7), kelampayoside A, sitosterol, and sitosteryl beta-D-glucoside, were isolated from the bark of Nauclea orientalis. The structures of 1-4 were elucidated using 1D and 2D NMR spectral methods, including COSY, DEPT, HMQC, (13)C-(1)H HMBC, and (15)N-(1)H HMBC.

摘要

从东方乌檀树皮中分离出四种新生物碱，即乌檀碱A（1）、B（2）以及乌檀苷A（3）和B（4），同时还分离出六种已知化合物，即裂杯木酰胺（5）、长春酰胺（6）、矮牵牛苷（7）、克拉姆帕苷A、甾醇以及β-D-葡萄糖甾醇苷。采用一维和二维核磁共振光谱方法，包括COSY、DEPT、HMQC、（13）C-（1）H HMBC和（15）N-（1）H HMBC对1-4的结构进行了阐明。