柔红霉素聚酮合酶基因合成芳香族最小聚酮化合物揭示了异源DpsY和JadI环化酶的不兼容性。
Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases.
作者信息
Wohlert S E, Wendt-Pienkowski E, Bao W, Hutchinson C R
机构信息
School of Pharmacy, University of Wisconsin, 425 N. Charter Street, Madison, Wisconsin 53706, USA.
出版信息
J Nat Prod. 2001 Aug;64(8):1077-80. doi: 10.1021/np010067f.
PMID:11520231
Abstract
Our investigations into whether the biosynthesis of a linearly fused ring system of an aromatic polyketide (jadomycin) could be modified to produce an angularly fused system (daunorubicin) and vice versa showed that introduction of the respective cyclases did not have the desired effect. Genes from the daunorubicin pathway produced a novel 21-carbon polyketide.
摘要
我们对能否修饰芳香族聚酮化合物（柔红霉素）的线性稠合环系统的生物合成以产生角形稠合系统（柔红霉素），反之亦然进行了研究，结果表明引入各自的环化酶并没有产生预期的效果。来自柔红霉素途径的基因产生了一种新的21碳聚酮化合物。
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