Rich-Edwards J, Krieger N, Majzoub J, Zierler S, Lieberman E, Gillman M
Department of Ambulatory Care and Prevention, Harvard Medical School/Harvard Pilgrim Health Care, 133 Brookline Avenue, Boston, MA 02215, USA.
Paediatr Perinat Epidemiol. 2001 Jul;15 Suppl 2:124-35. doi: 10.1046/j.1365-3016.2001.00013.x.
Chronic psychological stress may raise the risk of preterm delivery by raising levels of placental corticotropin-releasing hormone (CRH). Women who have been the targets of racism or personal violence may be at particularly high risk of preterm delivery. The aims of this study are to examine the extent to which: (1) maternal experiences of racism or violence in childhood, adulthood, or pregnancy are associated with the risk of preterm birth; (2) CRH levels are prospectively associated with risk of preterm birth; and (3) CRH levels are associated with past and current maternal experiences of racism or violence. We have begun to examine these questions among women enrolled in Project Viva, a Boston-based longitudinal study of 6000 pregnant women and their children.
慢性心理压力可能通过提高胎盘促肾上腺皮质激素释放激素（CRH）水平来增加早产风险。遭受种族主义或人身暴力的女性可能面临特别高的早产风险。本研究的目的是探讨以下方面的程度：（1）母亲在童年、成年或孕期遭受种族主义或暴力的经历与早产风险之间的关联；（2）CRH水平与早产风险的前瞻性关联；（3）CRH水平与母亲过去和当前遭受种族主义或暴力的经历之间的关联。我们已开始在参加“活力计划”的女性中研究这些问题，该计划是一项基于波士顿的对6000名孕妇及其子女的纵向研究。
