Gross J A, Dillon S R, Mudri S, Johnston J, Littau A, Roque R, Rixon M, Schou O, Foley K P, Haugen H, McMillen S, Waggie K, Schreckhise R W, Shoemaker K, Vu T, Moore M, Grossman A, Clegg C H
Department of Immunology, 1201 Eastlake Avenue East, Seattle, WA 98102, USA.
Immunity. 2001 Aug;15(2):289-302. doi: 10.1016/s1074-7613(01)00183-2.
BLyS and APRIL have similar but distinct biological roles, mediated through two known TNF receptor family members, TACI and BCMA. We show that mice treated with TACI-Ig and TACI-Ig transgenic mice have fewer transitional T2 and mature B cells and reduced levels of circulating immunoglobulin. TACI-Ig treatment inhibits both the production of collagen-specific Abs and the progression of disease in a mouse model of rheumatoid arthritis. In BLyS-deficient mice, B cell development is blocked at the transitional T1 stage such that virtually no mature B cells are present, while B-1 cell numbers are relatively normal. These findings further elucidate the roles of BLyS and APRIL in modulating B cell development and suggest that BLyS is required for the development of most but not all mature B cell populations found in the periphery.
B淋巴细胞刺激因子（BLyS）和增殖诱导配体（APRIL）具有相似但不同的生物学作用，通过两种已知的肿瘤坏死因子受体家族成员——跨膜激活剂和钙调素结合蛋白（TACI）及B细胞成熟抗原（BCMA）介导。我们发现，用TACI-Ig处理的小鼠和TACI-Ig转基因小鼠的过渡性T2和成熟B细胞较少，循环免疫球蛋白水平降低。在类风湿性关节炎小鼠模型中，TACI-Ig治疗可抑制胶原特异性抗体的产生和疾病进展。在BLyS缺陷小鼠中，B细胞发育在过渡性T1阶段受阻，因此几乎没有成熟B细胞存在，而B-1细胞数量相对正常。这些发现进一步阐明了BLyS和APRIL在调节B细胞发育中的作用，并表明BLyS是外周发现的大多数但并非所有成熟B细胞群体发育所必需的。
