Brusés J L, Rutishauser U
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA.
Biochimie. 2001 Jul;83(7):635-43. doi: 10.1016/s0300-9084(01)01293-7.
The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) appeared during the evolution of vertebrates as a new mechanism for regulation of cell interactions. This large and abundant glycoprotein can exert steric effects at the cell surface that lead to the attenuation of cell-cell bonds mediated not only by NCAM but also a variety of other adhesion receptors. PSA-NCAM expression changes both as a result of developmental programs and physiological inputs. This global modulation of cell-cell attachment has been shown to facilitate cell migration, axon pathfinding and targeting, and plastic changes in the embryonic and adult nervous system.
神经细胞黏附分子的多唾液酸化形式（PSA-NCAM）在脊椎动物进化过程中作为一种调节细胞相互作用的新机制出现。这种大量且丰富的糖蛋白可在细胞表面发挥空间效应，导致不仅由NCAM介导，而且由多种其他黏附受体介导的细胞间连接减弱。PSA-NCAM的表达因发育程序和生理输入而发生变化。这种对细胞间附着的全局调节已被证明有助于细胞迁移、轴突寻路和靶向，以及胚胎和成年神经系统中的可塑性变化。
