Weitschies W, Hartmann V, Grützmann R, Breitkreutz J
Ernst-Moritz-Arndt-University, Institute of Pharmacy, Friedrich-Ludwig-Jahn-Strasse 17, D-17498 Greifswald, Germany.
Eur J Pharm Biopharm. 2001 Sep;52(2):221-6. doi: 10.1016/s0939-6411(01)00178-3.
The disintegration behavior of different tablets that were marked as magnetic dipoles by the incorporation of ferromagnetic black iron oxide and subsequent magnetization was studied using a specially developed measurement setup. This novel apparatus records the magnetic induction generated by the magnetic dipole moment of the tablets during their disintegration. It was found that the observed decrease of the magnetic induction can be used for a quantitative determination of the disintegration of tablets. In particular, it could be shown that the magnetic data provide information about the disintegration mechanism. For tablets with a minor influence of swelling on the disintegration mechanism a linear decline of the magnetic fluxes was observed. After addition of swelling disintegrants (crospovidone) the decline of the magnetic flux could be fitted by an exponential function, indicating the involvement of a disintegration force. Furthermore, the data demonstrate that using modern multichannel biomagnetic measurement equipment the monitoring of the disintegration behavior of magnetically marked tablets in humans will be possible.
通过掺入铁磁黑色氧化铁并随后进行磁化，将不同片剂标记为磁偶极子，利用专门开发的测量装置研究了它们的崩解行为。这种新型仪器记录了片剂崩解过程中由磁偶极矩产生的磁感应。结果发现，观察到的磁感应下降可用于定量测定片剂的崩解情况。特别是，可以表明磁性数据提供了有关崩解机制的信息。对于溶胀对崩解机制影响较小的片剂，观察到磁通量呈线性下降。加入溶胀崩解剂（交联聚维酮）后，磁通量的下降可用指数函数拟合，表明存在崩解力。此外，数据表明，使用现代多通道生物磁测量设备，有可能监测人体中磁性标记片剂的崩解行为。
