Weitschies Werner, Kosch Olaf, Mönnikes Hubert, Trahms Lutz
Ernst-Moritz-Arndt-University, Institute of Pharmacy, Friedrich-Ludwig-Jahn-Strasse 17, D-17498 Greifswald, Germany.
Adv Drug Deliv Rev. 2005 Jun 15;57(8):1210-22. doi: 10.1016/j.addr.2005.01.025. Epub 2005 Apr 8.
Magnetic Marker Monitoring offers an alternative to investigate the behavior of solid dosage forms in the organs of the gastrointestinal tract without the need to apply radiation. For Magnetic Marker Monitoring, the dosage form is marked as a permanent magnetic dipole by the incorporation of small amounts of ferromagnetic material, as for example the colorant black iron oxide, and subsequent magnetization. Thereby, the dosage form is labeled as the source of a well defined magnetic field, which can be measured using a measurement technique that is established for biomagnetic investigations. Using the established concepts for magnetic source localization, the three dimensional localization and orientation as well as the strength of the magnetic source can be reconstructed from these magnetic measurement data as a function of time. Furthermore, it is possible to gain quantitative information on the disintegration of dosage forms in vivo. Examples are given for results obtained concerning the esophageal transit, the gastric and the intestinal behavior of capsules and tablets.
磁性标记监测提供了一种无需应用辐射即可研究固体剂型在胃肠道器官中行为的替代方法。对于磁性标记监测，通过掺入少量铁磁材料（例如着色剂黑色氧化铁）并随后进行磁化，将剂型标记为永久磁偶极子。由此，剂型被标记为一个定义明确的磁场源，该磁场可以使用为生物磁学研究建立的测量技术进行测量。利用已确立的磁源定位概念，可以根据这些磁测量数据重建磁源的三维定位、方向以及强度随时间的变化。此外，还可以获得有关剂型在体内崩解的定量信息。文中给出了关于胶囊和片剂在食管转运、胃和肠道行为方面所获结果的示例。
