Demin A A, Demin A A
Kardiologiia. 1975 May;15(5):32-9.
A study of 1000 cases of septic endocarditis served as a basis for an analysis of the natural history of the diseases (1939-1972): changes in its etiology, clinical course and therapy. The increasing frequency of hospital infection (endocarditis) is emphasized. The characteristics of Staphylococcal and fungal endocarditis are presented, those of the lesion developing on heart valve prostheses as well. The classification of septic endocarditis is analysed, the stages of its activeness are described (III, II, I) along with the clinical and laboratory signs. Schemes of etiotropic therapy are presented, as well as rational combinations of antibiotics. The role of surgery in the management of primary septic endocarditis is described, and the rationale of preventive employment of antibiotics is discussed.
一项对1000例感染性心内膜炎病例的研究为分析该疾病（1939年至1972年）的自然史奠定了基础：病因、临床病程及治疗方面的变化。强调了医院感染（心内膜炎）发生率的上升。介绍了葡萄球菌性和真菌性心内膜炎的特点，以及心脏瓣膜假体上发生病变的特点。分析了感染性心内膜炎的分类，描述了其活动期（III期、II期、I期）以及临床和实验室体征。给出了病因特异性治疗方案以及抗生素的合理联合使用方法。描述了手术在原发性感染性心内膜炎治疗中的作用，并讨论了预防性使用抗生素的理论依据。
