Kay P H, Oldershaw P J, Lincoln J C, Lennox S C, Paneth M
J Cardiovasc Surg (Torino). 1983 Mar-Apr;24(2):127-31.
During the period 1970 to 1980 2,945 patients underwent valve replacement at the Brompton Hospital. Thirty-one (1%) patients subsequently developed prosthetic valve endocarditis (P.V.E.). Twenty-one (0.7%) patients developed endocarditis within two months of valve replacement. Ten patients were treated medically, with seven deaths, whilst four of the eleven surgical cases died. There were ten cases of late P.V.E. occurring between two months and eight years after initial valve replacement (0.12% per annum). Eight patients were treated surgically, with two deaths, whilst both medical cases died. Thus 67% patients were effectively treated by immediate valve replacement, whilst only 25% medical cases survived. Actuarial survival curves predict a 41% five-year survival following surgery for P.V.E. We stress the importance of early diagnosis of this condition and recommend immediate valve replacement in all patients with P.V.E. developing signs of haemodynamic failure.
1970年至1980年期间，2945例患者在布朗普顿医院接受了瓣膜置换手术。其中31例（1%）患者随后发生了人工瓣膜心内膜炎（P.V.E.）。21例（0.7%）患者在瓣膜置换术后两个月内发生了心内膜炎。10例患者接受了内科治疗，7例死亡，而11例外科治疗病例中有4例死亡。有10例晚期P.V.E.发生在初次瓣膜置换术后两个月至八年之间（每年0.12%）。8例患者接受了外科治疗，2例死亡，而2例内科治疗病例均死亡。因此，67%的患者通过立即进行瓣膜置换得到了有效治疗，而内科治疗病例中只有25%存活。精算生存曲线预测，P.V.E.手术后五年生存率为41%。我们强调早期诊断这种疾病的重要性，并建议对所有出现血流动力学衰竭迹象的P.V.E.患者立即进行瓣膜置换。
