Stowell J R, Kiecolt-Glaser J K, Glaser R
Department of Psychiatry, Ohio State University, USA.
J Behav Med. 2001 Aug;24(4):323-39. doi: 10.1023/a:1010630801589.
This cross-sectional study investigated whether active and avoidance coping methods were differentially related to immune function depending on stress level. Perceived stress and coping method were assessed in 173 healthy older adults and related to the number and percentage of CD3+, CD4+, and CD8+ T lymphocytes as well as the proliferative response of peripheral blood leukocytes to phytohemagluttinin (PHA) and concanavalin A (Con A). Both active and avoidance coping significantly interacted with perceived stress on proliferative responses to both mitogens. Higher levels of active coping were significantly related to a more vigorous proliferative response to PHA and Con A, particularly at high stress levels. At low stress levels, active coping was not significantly related to proliferative responses, whereas avoidance coping was significantly associated with a greater proliferative response to Con A. These results suggest that the relationships between certain coping methods and immune function depend on perceived stress level.
这项横断面研究调查了积极应对和回避应对方法是否根据压力水平与免疫功能存在不同的关联。在173名健康老年人中评估了感知压力和应对方法，并将其与CD3 +、CD4 +和CD8 + T淋巴细胞的数量和百分比以及外周血白细胞对植物血凝素（PHA）和刀豆蛋白A（Con A）的增殖反应相关联。积极应对和回避应对在对两种有丝分裂原的增殖反应上均与感知压力存在显著交互作用。较高水平的积极应对与对PHA和Con A更强烈的增殖反应显著相关，尤其是在高压力水平下。在低压力水平下，积极应对与增殖反应无显著关联，而回避应对与对Con A的更大增殖反应显著相关。这些结果表明，某些应对方法与免疫功能之间的关系取决于感知压力水平。
